Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

GSTO1-IN-6

GSTO1-IN-6 is an allosteric and covalent GSTO1 inhibitor with an IC50 of 457 nM. GSTO1-IN-6 markedly reduces Lipopolysaccharides (LPS) -induced IL-1β (IC50 of 1.9 μM) and IL-18 (IC50 of 10. μM) secretion in human monocyte-derived macrophages. GSTO1-IN-6 covalently modifies GSTO1-Cys32, inducing conformational changes and protein destabilization. GSTO1-IN-6 can be used for the research of inflammatory diseases[1].

Product Specifications

UNSPSC

12352005

Target

Glutathione S-transferase; Interleukin Related

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease

Field of Research

Inflammation/Immunology

Smiles

O=C(N1CCC[C@@H]1C2=NN=C(S2)C3=CC=C(C=C3)C(F)(F)F)C=C

Molecular Formula

C16H14F3N3OS

Molecular Weight

353.36

References & Citations

[1]Sun Y, et al. Discovery of Potent, Allosteric GSTO1 Covalent Inhibitors with a New Binding Mode. J Med Chem. 2025;68 (22) :24075-24093.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

IL-1; IL-18

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

OR6Q1 Antibody
8G669-AAT 50 µg

OR6Q1 Antibody

Sign In for Pricing
View Details
Human Kappa Light Chain (B-Cell Marker) (rL1C1), 0.2mg/mL
BNUB2222-100 1x 100 µL

Human Kappa Light Chain (B-Cell Marker) (rL1C1), 0.2mg/mL

Sign In for Pricing
View Details
Beta-2 Microglobulin (Renal Failure &Tumor Marker) (rB2M/961), CF740 conjugate, 0.1mg/mL
BNC741537-500 1x 500 µL

Beta-2 Microglobulin (Renal Failure &Tumor Marker) (rB2M/961), CF740 conjugate, 0.1mg/mL

Sign In for Pricing
View Details
Tissue Total RNA, Lung
CR562405 5 µg

Tissue Total RNA, Lung

Sign In for Pricing
View Details
Anti Human SLC29A1 Polyclonal
Y055349 100 µL

Anti Human SLC29A1 Polyclonal

Sign In for Pricing
View Details
COX17 Mouse Monoclonal Antibody [Clone ID: OTI3H4]
CF812201 100 µg

COX17 Mouse Monoclonal Antibody [Clone ID: OTI3H4]

Sign In for Pricing
View Details