GSTO1-IN-6
GSTO1-IN-6 is an allosteric and covalent GSTO1 inhibitor with an IC50 of 457 nM. GSTO1-IN-6 markedly reduces Lipopolysaccharides (LPS) (HY-D1056) -induced IL-1β (IC50 of 1.9 μM) and IL-18 (IC50 of 10. μM) secretion in human monocyte-derived macrophages. GSTO1-IN-6 covalently modifies GSTO1-Cys32, inducing conformational changes and protein destabilization. GSTO1-IN-6 can be used for the research of inflammatory diseases[1].
Product Specifications
UNSPSC
12352005
Target
Glutathione S-transferase; Interleukin Related
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology
Smiles
O=C(N1CCC[C@@H]1C2=NN=C(S2)C3=CC=C(C=C3)C(F)(F)F)C=C
Molecular Formula
C16H14F3N3OS
Molecular Weight
353.36
References & Citations
[1]Sun Y, et al. Discovery of Potent, Allosteric GSTO1 Covalent Inhibitors with a New Binding Mode. J Med Chem. 2025;68 (22) :24075-24093.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-1; IL-18
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