ZLMT-72
ZLMT-72 is an orally active dual CDK2 and CDK9 inhibitor with IC50s of 0.741 nM and 1.03 nM, respectively. ZLMT-72 shows good selectivity in kinase profiling andcholinesterase inhibition activity. ZLMT-72 has strong antiproliferative effects in the colorectal cancer (CRC) cell line HCT116 (GI50 apoptosis by inhibiting thephosphorylation of retinoblastoma and RNA polymerase II, resulting in downregulation of antiapoptotic proteins (Mcl-1 and XIAP) . ZLMT-72 can be used for the study of colorectal cancer (CRC) [1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family; CDK; DNA/RNA Synthesis; IAP
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
O=C([C@@H]1[C@@H](F)C1)NC2=CC(C3=CC=C(N=C(CCCCC4)C4=C5N6C[C@@H](CNC7)[C@@H]7C6)C5=C3)=CC=N2
Molecular Formula
C29H32FN5O
Molecular Weight
485.60
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK2; CDK9; Mcl-1; XIAP
Frequently Asked Questions
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