2DG-ODDA
2DG-ODDA is a 2-deoxyglucose (2-DG) derivative with potent antitumor activity. 2DG-ODDA induces apoptosis, and reduces ATP production. 2DG-ODDA is taken up through both fatty acid and glucose transporters and is cleaved by α-Mannosidase (HY-P2950), releases 2DG to inhibit N-glycosylation and disrupt cellular metabolism. 2DG-ODDA inhibits tumor growth in a 4T1 mouse model. 2DG-ODDA can be used for the research of triple-negative breast cancer (TNBC).
Product Specifications
UNSPSC
12352005
Target
Apoptosis
Related Pathways
Apoptosis
Field of Research
Cancer
Smiles
O=C(N[C@H](CO[C@H]1O[C@H](CO)[C@@H](O)[C@@H](O)C1)C(OC)=O)CCCCCCCCCCCCCCCCC(O)=O
Molecular Formula
C28H51NO10
Molecular Weight
561.71
References & Citations
[1]Jeon S, et al. Exploiting Metabolic Vulnerabilities in Cancer with a Dual-Transporter-Targeted 2-Deoxyglucose Analogue for Low-Dose, Potent Antitumor Activity. J Am Chem Soc. 2025;147 (47) :43267-43272.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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