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CGAS-IN-7

CGAS-IN-7 is a cyclic GMP-AMP synthase (cGAS) inhibitor with an IC50 of 0.66 μM for human cGAS. cGAS-IN-7 modestly decreases cGAMP levels in THP1 cells. cGAS-IN-7 can be used for the research of Alzheimer's disease[1].

Product Specifications

UNSPSC

12352101

Target

Cyclic GMP-AMP Synthase

Related Pathways

Immunology/Inflammation

Field of Research

Neurological Disease

Smiles

O=C(NS(=O)(C1=CC=C(OCC)C(Br)=C1)=O)CC2=CC=C(I)C=C2

Molecular Formula

C16H15BrINO4S

Molecular Weight

524.17

References & Citations

[1]Alarcón-Espósito J, et al. High-Throughput Screening and Initial SAR Studies Identify a Novel Submicromolar Potent Human cGAS Inhibitor. ACS Chem Biol. 2025;20 (12) :2886-2896.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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