EQ-04
EQ-04 is a highly selective positive allosteric modulator (PAM) of α7 nAChR. EQ-04 has no direct inhibitory activity on AChE and BChE. EQ-04 inhibits Aβ aggregation. EQ-04 has safe cytotoxicity and potent neuroprotective activity. EQ-04 can be used for the study of Alzheimer's disease.
Product Specifications
UNSPSC
12352005
Target
Amyloid-β; Cholinesterase (ChE)
Related Pathways
Neuronal Signaling
Field of Research
Neurological Disease
Smiles
N12CC(OC3=CC=C(C#CC4=CC=CC=C4)N=C3)C(CC2)CC1
Molecular Formula
C20H20N2O
Molecular Weight
304.39
References & Citations
[1]Cavagnero PS, et al. Neuroprotective Activity of 3- ((6- (Phenylethynyl) pyridin-3-yl) oxy) quinuclidine: A Potential Ligand for the Treatment of Alzheimer's Disease. ACS Chem Neurosci. 2025 Dec 3;16 (23) :4502-4510.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE
Curated Selection
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