EQ-04

EQ-04 is a highly selective positive allosteric modulator (PAM) of α7 nAChR. EQ-04 has no direct inhibitory activity on AChE and BChE. EQ-04 inhibits Aβ aggregation. EQ-04 has safe cytotoxicity and potent neuroprotective activity. EQ-04 can be used for the study of Alzheimer's disease.

Product Specifications

UNSPSC

12352005

Target

Amyloid-β; Cholinesterase (ChE)

Related Pathways

Neuronal Signaling

Field of Research

Neurological Disease

Smiles

N12CC(OC3=CC=C(C#CC4=CC=CC=C4)N=C3)C(CC2)CC1

Molecular Formula

C20H20N2O

Molecular Weight

304.39

References & Citations

[1]Cavagnero PS, et al. Neuroprotective Activity of 3- ((6- (Phenylethynyl) pyridin-3-yl) oxy) quinuclidine: A Potential Ligand for the Treatment of Alzheimer's Disease. ACS Chem Neurosci. 2025 Dec 3;16 (23) :4502-4510.