Entadamide A-CO-C12

Entadamide A-CO-C12 is an Entadamide A (HY-N12125) derivative with potent anti-cancer activity, particularly against breast cancer cell lines. Entadamide A-CO-C12 promotes apoptosis, suppresses migratory ability, sphere formation, and stem-like cell populations. Entadamide A-CO-C12 inhibits tumor growth in a 4T1 mouse model. Entadamide A-CO-C12 can be used for the research of breast cancer[1].

Product Specifications

UNSPSC

12352211

Target

Apoptosis; Bcl-2 Family; Reactive Oxygen Species (ROS) ; Survivin

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Field of Research

Cancer

Smiles

CCCCCCCCCCCCC(OCCNC(/C=C/SC)=O)=O

Molecular Formula

C19H35NO3S

Molecular Weight

357.55

References & Citations

[1]Bhulakshmi S, et al. Design and synthesis of Entadamide A derivatives targeting breast cancer: Insights into In silico, In vitro and In vivo models. Eur J Med Chem. 2026;302 (Pt 1) :118308.