PARP1-IN-50

PARP1-IN-50 is a selective and orally active PARP-1 inhibitor with an IC50 of 64.98 nM. PARP1-IN-50 can inhibit PAR formation and induce DNA double strand breaks, thereby causing DNA damage. PARP1-IN-50 can induce G2/M phase arrest and cancer cells apoptosis. PARP1-IN-50 demonstrates significant antiproliferative activity against various cancer cells. PARP1-IN-50 can be used for the research of cancer, such as breast cancer[1].

Product Specifications

CAS Number

[2255341-36-5]

UNSPSC

12352005

Target

Apoptosis; Bcl-2 Family; CDK; DNA/RNA Synthesis; PARP

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

NC(N/N=C/C1=CC(Br)=C(OCCCCOC2=C(C=C(C=C2Br)/C=N/NC(N)=S)OC)C(OC)=C1)=S

Molecular Formula

C22H26Br2N6O4S2

Molecular Weight

662.42

References & Citations

[1]Wang L, et al. Discovery of novel thiosemicarbazone dimers as effective inhibitors of poly (ADP-ribose) polymerase-1 (PARP-1) for use in cancer therapy. Eur J Med Chem. 2026;302 (Pt 1) :118312.