LP-03

LP-03 is an antibacterial agent with selective activity against Methicillin-resistant Staphylococcus aureus (MRSA) . Its minimum inhibitory concentration (MIC) is 6.2 μM. LP-03 has an inhibitory effect on biofilm formation, but it is unable to effectively remove the formed biofilms. LP-03 can enhance membrane permeability, disrupt the membrane structure of MRSA cells, and does not cause significant membrane depolarization. LP-03 has no hemolytic toxicity and shows low mammalian cell toxicity. It can be used for research on MRSA infections[1].

Product Specifications

UNSPSC

12352005

Target

Bacterial

Related Pathways

Anti-infection

Field of Research

Infection

Smiles

[H][C@]12C(CC[C@]1(C(CC[C@@]3([C@@]2(OC([C@@]34[C@@]5(C(NC6=C5C=C(C=C6)Br)=O)N7CCC[C@H]7C4)=O)[H])[H])=C)[H])=C

Molecular Formula

C27H29BrN2O3

Molecular Weight

509.43

References & Citations

[1]Bhushan A, et al. Selective membrane disrupting dispiro-oxindole Dehydrocostuslactone hybrids with potent anti-MRSA, antibiofilm, and synergistic activity. Bioorg Chem. 2025 Dec;167:109230.