LUF8100
LUF8100 is a dual-target antagonist of CCR2/CCR5 with pKi values for CCR2 and CCR5 of 5.23 and 4.97 respectively. LUF8100 can be used for research on immune homeostasis and cancer[1].
Product Specifications
CAS Number
[2954281-30-0]
UNSPSC
12352005
Target
CCR
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Smiles
O=S(NC1=CC(N2CCCCC2)=CC=C1)(C3=CC=C(Cl)C(C(F)(F)F)=C3)=O
Molecular Formula
C18H18ClF3N2O2S
Molecular Weight
418.86
References & Citations
[1]Essa K, et al. Combining AlphaFold with Focused Virtual Library Design in the Development of Novel CCR2 and CCR5 Antagonists. J Chem Inf Model. 2025 Nov 24;65 (22) :12398-12409.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CCR2; CCR5
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
![(E) -2-[ (2-Chlorophenyl) methylene]-4-[2- (1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl) ethoxy]-3-oxobutanoic Acid Ethyl Ester](https://cdn.genprice.uk/genprice/uk/genprice4.webp)
447848-01 10 mg
(E) -2-[ (2-Chlorophenyl) methylene]-4-[2- (1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl) ethoxy]-3-oxobutanoic Acid Ethyl Ester
Ask
View Details