LUF8100

LUF8100 is a dual-target antagonist of CCR2/CCR5 with pKi values for CCR2 and CCR5 of 5.23 and 4.97 respectively. LUF8100 can be used for research on immune homeostasis and cancer[1].

Product Specifications

CAS Number

[2954281-30-0]

UNSPSC

12352005

Target

CCR

Related Pathways

GPCR/G Protein; Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Smiles

O=S(NC1=CC(N2CCCCC2)=CC=C1)(C3=CC=C(Cl)C(C(F)(F)F)=C3)=O

Molecular Formula

C18H18ClF3N2O2S

Molecular Weight

418.86

References & Citations

[1]Essa K, et al. Combining AlphaFold with Focused Virtual Library Design in the Development of Novel CCR2 and CCR5 Antagonists. J Chem Inf Model. 2025 Nov 24;65 (22) :12398-12409.