RWT9996

RWT9996 is a balanced GPR17 antagonist. RWT9996 has an inhibitory effect on G protein activation and β-arrestin-2 recruitment induced by MDL-29951. RWT9996 inhibits the phosphorylation of ERK/CREB and the accumulation of inositol phosphate (b IP1) induced by MDL-29951. RWT9996 can be used for the study of neurological diseases[1].

Product Specifications

CAS Number

[2877694-62-5]

UNSPSC

12352005

Target

Arrestin; Epigenetic Reader Domain; ERK; Transmembrane Glycoprotein

Related Pathways

Epigenetics; GPCR/G Protein; Immunology/Inflammation; MAPK/ERK Pathway; Stem Cell/Wnt

Field of Research

Neurological Disease

Smiles

FC1=C(NS(C2=CNC(C3=CC=CC=C3)=C2)(=O)=O)C=CC(C#N)=C1

Molecular Formula

C17H12FN3O2S

Molecular Weight

341.36

References & Citations

[1]McDonald JK, et al. G Protein: β-Arrestin Bias Confers Differential Regulation of Gαq Signaling by GPR17 Antagonists. ACS Chem Neurosci. 2025 Dec 3;16 (23) :4479-4491.