RWT9996
RWT9996 is a balanced GPR17 antagonist. RWT9996 has an inhibitory effect on G protein activation and β-arrestin-2 recruitment induced by MDL-29951. RWT9996 inhibits the phosphorylation of ERK/CREB and the accumulation of inositol phosphate (b IP1) induced by MDL-29951. RWT9996 can be used for the study of neurological diseases[1].
Product Specifications
CAS Number
2877694-62-5
UNSPSC
12352005
Target
Arrestin; Epigenetic Reader Domain; ERK; Transmembrane Glycoprotein
Related Pathways
Epigenetics; GPCR/G Protein; Immunology/Inflammation; MAPK/ERK Pathway; Stem Cell/Wnt
Field of Research
Neurological Disease
Smiles
FC1=C(NS(C2=CNC(C3=CC=CC=C3)=C2)(=O)=O)C=CC(C#N)=C1
Molecular Formula
C17H12FN3O2S
Molecular Weight
341.36
References & Citations
[1]McDonald JK, et al. G Protein: β-Arrestin Bias Confers Differential Regulation of Gαq Signaling by GPR17 Antagonists. ACS Chem Neurosci. 2025 Dec 3;16 (23) :4479-4491.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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