AR ligand-49

AR ligand-49 (Compound 4q) is a dual ligand for the adenosine A2A receptor (A2AAR) and the A3 receptor (A3AR) . Its Ki values are 15 and 4.5 nM respectively. AR ligand-49 exhibits reverse agonistic activity at hA2AAR and antagonistic activity at hA3AR. AR ligand-49 can be used for the study of the design and development of adenosine receptor ligands[1].

Product Specifications

UNSPSC

12352005

Target

Androgen Receptor

Related Pathways

Vitamin D Related/Nuclear Receptor

Field of Research

Others

Smiles

NC1=NC(NC2=C(N3CCOCC3)C=CC=C2)=NC4=C1N=CN4[C@@H]5SC[C@@H](O)[C@H]5O

Molecular Formula

C19H23N7O3S

Molecular Weight

429.50

References & Citations

[1]Joung M, et al. Design, Synthesis, and Biological Evaluation of C2- (N-Substituted Amino) Truncated 4'-Thioadenosine Derivatives as A2AAR and A3AR Dual Ligands. ACS Med Chem Lett. 2025 Nov 14;16 (12) :2512-2519.