AR ligand-49
AR ligand-49 (Compound 4q) is a dual ligand for the adenosine A2A receptor (A2AAR) and the A3 receptor (A3AR) . Its Ki values are 15 and 4.5 nM respectively. AR ligand-49 exhibits reverse agonistic activity at hA2AAR and antagonistic activity at hA3AR. AR ligand-49 can be used for the study of the design and development of adenosine receptor ligands[1].
Product Specifications
UNSPSC
12352005
Target
Androgen Receptor
Related Pathways
Vitamin D Related/Nuclear Receptor
Field of Research
Others
Smiles
NC1=NC(NC2=C(N3CCOCC3)C=CC=C2)=NC4=C1N=CN4[C@@H]5SC[C@@H](O)[C@H]5O
Molecular Formula
C19H23N7O3S
Molecular Weight
429.50
References & Citations
[1]Joung M, et al. Design, Synthesis, and Biological Evaluation of C2- (N-Substituted Amino) Truncated 4'-Thioadenosine Derivatives as A2AAR and A3AR Dual Ligands. ACS Med Chem Lett. 2025 Nov 14;16 (12) :2512-2519.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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