PROTAC 11β-HSD1 Degrader 1
PROTAC 11β-HSD1 Degrader 1 is a highly efficient PROTAC targeting 11β-HSD1 (Hydroxysteroid 11-beta dehydrogenase 1) . PROTAC 11β-HSD1 Degrader 1 demonstrates ubiquitin-proteasome-dependent degradation of 11β-HSD1. PROTAC 11β-HSD1 Degrader 1 can be used for the study of type 2 diabetes mellitus (T2DM) [1].
Product Specifications
UNSPSC
12352005
Target
11β-HSD; PROTACs
Related Pathways
Metabolic Enzyme/Protease; PROTAC
Field of Research
Metabolic Disease
Smiles
O=C(C1=C(C(C)(C)C)N(C2=CC=C(C(NCC3=CN(CCOCCOCCOCCC(N[C@H](C(N4[C@H](C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)C[C@@H](O)C4)=O)C(C)(C)C)=O)N=N3)=O)C=C2)N=C1)NC78CC9CC(C8)CC(C9)C7
Molecular Formula
C59H79N11O9S
Molecular Weight
1118.39
References & Citations
[1]Wang L, et al. Design, synthesis, and pharmacological evaluation of novel PROTAC degraders targeting 11β-HSD1 for metabolic disease intervention [preprint]. bioRxiv [Internet]. 2025 Nov 09
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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