Dyrk1A-IN-16
Dyrk1A-IN-16 is a selective, brain-penetrant and ATP-competitive Dyrk1A inhibitor with a IC50 of 53 nM. Dyrk1A-IN-16 displays high selectivity across a broad kinase panel (specific for DYRK kinases) with nanomolar potency. Dyrk1A-IN-16 impairs neurosphere self-renewal, cell invasion, and EGFR stability in vitro. Dyrk1A-IN-16 inhibits tumor growth and prolongs survival in vivo. Dyrk1A-IN-16 has potential for glioblastoma (GBM) research[1].
Product Specifications
CAS Number
2805339-74-4
UNSPSC
12352005
Target
DYRK; EGFR
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Field of Research
Cancer; Neurological Disease
Smiles
OC1=C(O)C=C(SC(C(C2=CC=C(O)C(O)=C2)=O)=N3)C3=C1
Molecular Formula
C14H9NO5S
Molecular Weight
303.29
References & Citations
[1]Venkataramani P, et al. Novel small-molecule inhibitors of the protein kinase DYRK: Potential therapeutic candidates in cancer. bioRxiv [Preprint]. 2025 Nov 7:2025.11.05.686653.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
DYRK1
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