Dyrk1A-IN-16

Dyrk1A-IN-16 is a selective, brain-penetrant and ATP-competitive Dyrk1A inhibitor with a IC50 of 53 nM. Dyrk1A-IN-16 displays high selectivity across a broad kinase panel (specific for DYRK kinases) with nanomolar potency. Dyrk1A-IN-16 impairs neurosphere self-renewal, cell invasion, and EGFR stability in vitro. Dyrk1A-IN-16 inhibits tumor growth and prolongs survival in vivo. Dyrk1A-IN-16 has potential for glioblastoma (GBM) research[1].

Product Specifications

CAS Number

[2805339-74-4]

UNSPSC

12352005

Target

DYRK; EGFR

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Field of Research

Cancer; Neurological Disease

Smiles

OC1=C(O)C=C(SC(C(C2=CC=C(O)C(O)=C2)=O)=N3)C3=C1

Molecular Formula

C14H9NO5S

Molecular Weight

303.29

References & Citations

[1]Venkataramani P, et al. Novel small-molecule inhibitors of the protein kinase DYRK: Potential therapeutic candidates in cancer. bioRxiv [Preprint]. 2025 Nov 7:2025.11.05.686653.