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HTS10307

HTS10307 is a small molecule AP1 Transcription Factor ΔFOSB inhibitor. HTS10307 inhibits the binding of ΔFOSB/JUND and ΔFOSB to DNA with IC50 values of ~3 μM and ~7 μM, respectively. HTS10307 can be used as a chemical probe for investigating the role of ΔFOSB in pathological conditions such as drug addiction, Alzheimer’s disease, and Parkinson’s disease[1].

Product Specifications

CAS Number

81682-91-9

UNSPSC

12352005

Target

AP-1

Related Pathways

Immunology/Inflammation

Field of Research

Neurological Disease

Smiles

O=C(N1)C(C#N)=C(C2=CC=CO2)C=C1C3=CC=CS3

Molecular Formula

C14H8N2O2S

Molecular Weight

268.29

References & Citations

[1]Sean McNeme, et al. Discovery of Small Molecules and a Druggable Groove That Regulate DNA Binding and Release of the AP1 Transcription Factor ΔFOSB. bioRxiv. October 23, 2025.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

FosB

Frequently Asked Questions

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