GM47-1
GM47-1, a naphthalene scaffold derivative, is a potent mycolic acid transporter MmpL3 inhibitor exhibiting potent bactericidal activity against Mycobacterium abscessus (Mabs) with an MIC50 of 2.1 µM. GM47-1 targets MmpL3, disrupts cell wall integrity, and induces ATP leakage and uncouples respiration. GM47-1 can be used for Mycobacterium abscessus pulmonary disease (Mabs-PD) research[1].
Product Specifications
UNSPSC
12352005
Target
Bacterial
Related Pathways
Anti-infection
Field of Research
Inflammation/Immunology
Smiles
CCOC1=CC=C(C=C1)CCNCC2=CC=C(C3=CC=CC=C23)OC
Molecular Formula
C22H25NO2
Molecular Weight
335.44
References & Citations
[1]Samsher Singh, et al. A bioluminescence-based chemical screen identifies a bactericidal naphthalene scaffold targeting MmpL3 in Mycobacterium abscessus. bioRxiv. October 26, 2025.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
![[1- (4'-Bromo[1,1'-biphenyl]-4-yl) -2-phenylethyl]malonic acid](https://cdn.genprice.uk/genprice/uk/genprice5.webp)
OR98275 1 Each
[1- (4'-Bromo[1,1'-biphenyl]-4-yl) -2-phenylethyl]malonic acid
Sign In for Pricing
View Details PC1025012-01 250 mg
3- (benzyloxy) -2-fluoro-4- (trifluoromethyl) benzaldehyde
Sign In for Pricing
View Details PC1025012-02 500 mg
3- (benzyloxy) -2-fluoro-4- (trifluoromethyl) benzaldehyde
Sign In for Pricing
View Details PC1025012-03 1 g
3- (benzyloxy) -2-fluoro-4- (trifluoromethyl) benzaldehyde
Sign In for Pricing
View Details PC1025012-04 5 g
3- (benzyloxy) -2-fluoro-4- (trifluoromethyl) benzaldehyde
Sign In for Pricing
View Details PC1025012-05 10 g
3- (benzyloxy) -2-fluoro-4- (trifluoromethyl) benzaldehyde
Sign In for Pricing
View Details