GM47-1
GM47-1, a naphthalene scaffold derivative, is a potent mycolic acid transporter MmpL3 inhibitor exhibiting potent bactericidal activity against Mycobacterium abscessus (Mabs) with an MIC50 of 2.1 µM. GM47-1 targets MmpL3, disrupts cell wall integrity, and induces ATP leakage and uncouples respiration. GM47-1 can be used for Mycobacterium abscessus pulmonary disease (Mabs-PD) research[1].
Product Specifications
UNSPSC
12352005
Target
Bacterial
Related Pathways
Anti-infection
Field of Research
Inflammation/Immunology
Smiles
CCOC1=CC=C(C=C1)CCNCC2=CC=C(C3=CC=CC=C23)OC
Molecular Formula
C22H25NO2
Molecular Weight
335.44
References & Citations
[1]Samsher Singh, et al. A bioluminescence-based chemical screen identifies a bactericidal naphthalene scaffold targeting MmpL3 in Mycobacterium abscessus. bioRxiv. October 26, 2025.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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