PROTAC DNPH1 Degrader 1

PROTAC DNPH1 Degrader 1 (Compound 59) is a PROTAC DNPH1 degrader with a DC50 of 28 nM. PROTAC DNPH1 Degrader 1 promotes the ubiquitination and degradation of DNPH1. PROTAC DNPH1 Degrader 1 has sufficient potency to enhance hmdU sensitivity. PROTAC DNPH1 Degrader 1 can be used in cancer research[1].

Product Specifications

UNSPSC

12352005

Target

Glycosidase; Ligands for E3 Ligase; PROTACs

Related Pathways

Metabolic Enzyme/Protease; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

CNC1=NC(NC2=C(C=C(C=C2)C(O)=O)C3=CC=CC(C(F)(F)F)=C3)=NC4=CC=C(C=C41)OC5=CC=C(C=C5)CN(CCCCCC6=CN([C@H](C(N7C[C@H](O)C[C@H]7C(N[C@@H](C)C8=CC=C(C9=C(C)N=CS9)C=C8)=O)=O)C(C)C)N=N6)C

Molecular Formula

C60H64F3N11O6S

Molecular Weight

1124.28

References & Citations

[1]Anderson NA, et al. Use of Direct-to-Biology Strategies for the Discovery of 2'-Deoxynucleoside 5'-Monophosphate N-Glycosidase (DNPH1) PROTACs. J Med Chem. 2025 Nov 13;68 (21) :23421-23447.