EL244

EL244 is a dual ATX (IC50 = 50 nM) inhibitor and PPARγ (IC50 = 1.3 μM; Kd = 1.3 μM) agonist. EL244 demonstrates low cytotoxicity in human HepG2 cells (EC50 = 81.2 μM) with minimal inhibition of the cardiac hERG potassium channel (12% at 25 μM) . EL244 significantly reduces pulmonary Lysophosphatidic Acid (LPA) levels, attenuates fibrosis, and restores respiratory function with limited systemic absorption in vivo. EL244 can be used for idiopathic pulmonary fibrosis and interstitial lung disease (ILD) research[1].

Product Specifications

CAS Number

[3047548-70-6]

UNSPSC

12352005

Target

Phosphodiesterase (PDE) ; PPAR

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Field of Research

Inflammation/Immunology

Smiles

O=C1NC(C(S1)CC2=CC=C(C=C2)OCCC3CCN(CC3)C(OCC4=CC(Cl)=CC(Cl)=C4)=O)=O

Molecular Formula

C25H26Cl2N2O5S

Molecular Weight

537.46

References & Citations

[1]Alexios N, et al. An aerosolised dual-action Autotaxin inhibitor-PPARγ agonist for the treatment of pulmonary fibrosis. Biorixiv. November 13, 2025.