PIN1 degrader-3
PIN1 degrader-3 is a Pin1 (peptidyl-prolyl isomerase protein) (IC50 = 4.65 nM) degrader. PIN1 degrader-3 bound covalently to Pin1. PIN1 degrader-3-induced Pin1 degradation reduced cell viability, with EC50 values after 72 h of 8.4 μM in MIA PaCa-2 cells and 5.3 μM in KPC cell lines.PIN1 degrader-3 can destabilize Pin1 in vitro, causing its degradation in cells. PIN1 degrader-3 can be used for the study of pancreatic cancer[1].
Product Specifications
CAS Number
3101950-55-1
UNSPSC
12352005
Target
PIN1
Related Pathways
PI3K/Akt/mTOR
Field of Research
Cancer
Smiles
O=C(NC)[C@@H](NC([C@@H]1CCCCN1C([C@@H](NC(CCl)=O)CC2=CNC3=C2C=CC(Cl)=C3)=O)=O)CC4=CNC5=C4C=CC=C5
Molecular Formula
C31H34Cl2N6O4
Molecular Weight
625.55
References & Citations
[1]Alboreggia G, et al. Pre-clinical evaluation of a potent and effective Pin1-degrading agent in pancreatic cancer. Mol Ther Oncol. 2025 Nov 1;33 (4) :201078.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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