CV2a
CV2a is a 14-3-3-directed molecular glue-based PROTAC that selectively targets the ERα protein complex with an EC50 of 0.10 μM. CV2a cooperatively recruits VHL to the 14-3-3/ERα complex and promotes robust polyubiquitination of the 14-3-3ζ/ERα complex[1].
Product Specifications
UNSPSC
12352005
Target
Estrogen Receptor/ERR; PROTACs
Related Pathways
PROTAC; Vitamin D Related/Nuclear Receptor
Field of Research
Others
Smiles
C[C@@]12/C=C3[C@](CC[C@]\3([H])COC)([H])[C@@H](C)[C@@H](O)[C@H](O[C@@H]4[C@H](O)[C@@H](O)[C@H](O)[C@@H](COC(C)(C)C=C)O4)C1=C(C(C)(CNC(CCCCCCCCCCCC(N[C@@H](C(C)(C)C)C(N5[C@H](C(NCC6=CC=C(C7=C(C)N=CS7)C=C6)=O)C[C@@H](O)C5)=O)=O)=O)C)C[C@@H]2O
Molecular Formula
C68H105N5O14S
Molecular Weight
1248.65
References & Citations
[1]Carlo J. A. Verhoef, et al. Induced ubiquitination of the partially disordered Estrogen Receptor alpha protein via a 14-3-3-directed molecular glue-based PROTAC design. bioRxiv. November 17, 2025.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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