CV2a

CV2a is a 14-3-3-directed molecular glue-based PROTAC that selectively targets the ERα protein complex with an EC50 of 0.10 μM. CV2a cooperatively recruits VHL to the 14-3-3/ERα complex and promotes robust polyubiquitination of the 14-3-3ζ/ERα complex[1].

Product Specifications

UNSPSC

12352005

Target

Estrogen Receptor/ERR; PROTACs

Related Pathways

PROTAC; Vitamin D Related/Nuclear Receptor

Field of Research

Others

Smiles

C[C@@]12/C=C3[C@](CC[C@]\3([H])COC)([H])[C@@H](C)[C@@H](O)[C@H](O[C@@H]4[C@H](O)[C@@H](O)[C@H](O)[C@@H](COC(C)(C)C=C)O4)C1=C(C(C)(CNC(CCCCCCCCCCCC(N[C@@H](C(C)(C)C)C(N5[C@H](C(NCC6=CC=C(C7=C(C)N=CS7)C=C6)=O)C[C@@H](O)C5)=O)=O)=O)C)C[C@@H]2O

Molecular Formula

C68H105N5O14S

Molecular Weight

1248.65

References & Citations

[1]Carlo J. A. Verhoef, et al. Induced ubiquitination of the partially disordered Estrogen Receptor alpha protein via a 14-3-3-directed molecular glue-based PROTAC design. bioRxiv. November 17, 2025.