CV2a
CV2a is a 14-3-3-directed molecular glue-based PROTAC that selectively targets the ERα protein complex with an EC50 of 0.10 μM. CV2a cooperatively recruits VHL to the 14-3-3/ERα complex and promotes robust polyubiquitination of the 14-3-3ζ/ERα complex[1].
Product Specifications
UNSPSC
12352005
Target
Estrogen Receptor/ERR; PROTACs
Related Pathways
PROTAC; Vitamin D Related/Nuclear Receptor
Field of Research
Others
Smiles
C[C@@]12/C=C3[C@](CC[C@]\3([H])COC)([H])[C@@H](C)[C@@H](O)[C@H](O[C@@H]4[C@H](O)[C@@H](O)[C@H](O)[C@@H](COC(C)(C)C=C)O4)C1=C(C(C)(CNC(CCCCCCCCCCCC(N[C@@H](C(C)(C)C)C(N5[C@H](C(NCC6=CC=C(C7=C(C)N=CS7)C=C6)=O)C[C@@H](O)C5)=O)=O)=O)C)C[C@@H]2O
Molecular Formula
C68H105N5O14S
Molecular Weight
1248.65
References & Citations
[1]Carlo J. A. Verhoef, et al. Induced ubiquitination of the partially disordered Estrogen Receptor alpha protein via a 14-3-3-directed molecular glue-based PROTAC design. bioRxiv. November 17, 2025.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
