AURKA-IN-4
AURKA-IN-4 (compound 13), a capsaicin-derived prohibitin ligand, is an AURKA inhibitor. AURKA-IN-4 acts as a molecular glue within the AURKA/PHB2/LC3 complex. AURKA-IN-4 is specific to the mitochondrial pool of AURKA, and inhibits AURKA-dependent mitophagy. AURKA-IN-4 can be used for cancer research[1].
Product Specifications
CAS Number
89575-11-1
UNSPSC
12352005
Target
Aurora Kinase; Mitochondrial Metabolism; Molecular Glues
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease; PROTAC
Field of Research
Cancer
Smiles
COC1=CC(CNC(CCC)=O)=CC=C1O
Molecular Formula
C12H17NO3
Molecular Weight
223.27
References & Citations
[1]Amel Djehal, et al. Development of capsaicin-derived prohibitin ligands to modulate the Aurora kinase A/PHB2 interaction and mitophagy in cancer cells. bioRxiv. November 15, 2025.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
