AURKA-IN-4
AURKA-IN-4 (compound 13), a capsaicin-derived prohibitin ligand, is an AURKA inhibitor. AURKA-IN-4 acts as a molecular glue within the AURKA/PHB2/LC3 complex. AURKA-IN-4 is specific to the mitochondrial pool of AURKA, and inhibits AURKA-dependent mitophagy. AURKA-IN-4 can be used for cancer research[1].
Product Specifications
CAS Number
89575-11-1
UNSPSC
12352005
Target
Aurora Kinase; Mitochondrial Metabolism; Molecular Glues
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease; PROTAC
Field of Research
Cancer
Smiles
COC1=CC(CNC(CCC)=O)=CC=C1O
Molecular Formula
C12H17NO3
Molecular Weight
223.27
References & Citations
[1]Amel Djehal, et al. Development of capsaicin-derived prohibitin ligands to modulate the Aurora kinase A/PHB2 interaction and mitophagy in cancer cells. bioRxiv. November 15, 2025.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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