UCM-A86
UCM-A86 is a selective positive allosteric modulator of GluN1/GluN3 NMDA receptors with EC50 values of 21 µM and 19 µM at GluN1/GluN3A and GluN1/GluN3B receptors, respectively. UCM-A86 selectively potentiates responses from GluN1/GluN3A/B over GluN1/GluN2A-D receptors. UCM-A86 can be used in the research of central nervous system diseases[1].
Product Specifications
CAS Number
[1210899-51-6]
UNSPSC
12352005
Target
IGluR
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
FC(C1=NN=C2C=CC(SC3=CC=C(C(C)C)C=C3)=NN21)(F)F
Molecular Formula
C15H13F3N4S
Molecular Weight
338.35
References & Citations
[1]Benton AJ, et al. UCM-A86 is a selective positive allosteric modulator of GluN1/GluN3 NMDA receptors. bioRxiv [Preprint]. 2025 Nov 16:2025.11.14.688378.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NMDA Receptor
Curated Selection
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