ZIP14-IN-1

ZIP 14-IN-1 (PPTD) is a selective and orally active ZIP14 inhibitor. ZIP 14-IN-1 inhibits ZIP14 while sparing ZIP8 (SLC39A8) . ZIP 14-IN-1 efficiently blocks ZIP14-mediated uptake of multiple divalent metals (zinc, iron, manganese and cadmium) . ZIP 14-IN-1 binds to a pocket formed at the dimer interface of ZIP14, obstructing the metal transport pathway. ZIP 14-IN-1 effectively reverses the consequent elevation of reactive oxygen species (ROS) and lipid peroxidation, attenuating metal-induced cytotoxicity. ZIP 14-IN-1 can be uses for cancer cachexia research[1].

Product Specifications

CAS Number

[1048-17-5]

Product Name Alternative

PPTD

UNSPSC

12352005

Target

Ferroptosis; Reactive Oxygen Species (ROS)

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=C1NCN(C2=CC=CC=C2)C13CCN(CCC4=CC=CC=C4)CC3

Molecular Formula

C21H25N3O

Molecular Weight

335.44

References & Citations

[1]Hara T, et al. Matsukawa K, Ujihara S, Kawabe T, Taguchi H, Fujishiro H, Jenkitkasemwong S, Nunomura K, Lin B, Fukunaka A, Yoshigai E, Mishima K, Nakagawa S, Knutson MD, Imagawa H, Matsunaga N, Ohdo S, Hamachi I, Sakurai H, Fukada T. Discovery of a Selective Inhibitor of ZIP14 with Therapeutic Potential for Cancer-associated Cachexia. bioRxiv [Preprint]. 2025 Oct 23:2025.10.23.682519.