F3288-0031
F3288-0031 is a brain-penetrant norepinephrine transporter (NET) allosteric inhibitor with inhibitory rates of 73.5% at 20 μM. F3288-0031 binds within the inner vestibule of NET, stabilizing the inward-open state and has a preferential NET/SERT inhibition with pIC50 = 5.9. F3288-0031 shows no detectable off-target functional activity in vitro. F3288-0031 demonstrates robust antidepressant-like efficacy in vivo without confounding locomotor effects, F3288-0031 can be used for depressive disorder and related neuropsychiatric conditions[1].
Product Specifications
CAS Number
[926493-93-8]
UNSPSC
12352005
Target
Monoamine Transporter
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Neurological Disease
Smiles
C/C=C/C1=CC(OC)=C(C=C1)OCC(CN2CCN(CC2)CC3=CC=CC=C3)O
Molecular Formula
C24H32N2O3
Molecular Weight
396.52
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
Recombinant Rat Protein-lysine 6-oxidase Protein, His, E.coli-500ug
