CHF-6333

CHF-6333 is a neutrophil elastase (NE) inhibitor (IC50 = 0.21 nM; KD = 0.16 nM) . CHF-6333 retains its activity in both human (IC50 = 0.22 nM) and rat (IC50 = 3.63 nM) proteases. CHF-6333 exhibits inhibitory activity against Proteinase 3 (IC50 = 22 nM) . CHF-6333 can be used for the study of bronchiectasis (BE) [1].

Product Specifications

UNSPSC

12352005

Target

Elastase

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Inflammation/Immunology

Smiles

CC(N1C2=CC(C(F)(F)F)=CC=C2)=C([C@H](N3C1=NNC3=O)C4=C(C=C(C=C4)C#N)CC[N+](C)(C)C)C(OC)=O.OC5=C(C=CC6=CC=CC=C65)C([O-])=O.O.O

Molecular Formula

C38H39F3N6O8

Molecular Weight

764.75

References & Citations

[1]Armani E, et al. Design, Synthesis, and Biological Evaluation of the Novel Neutrophil Elastase Inhibitor CHF-6333 for the Inhaled Treatment of Bronchiectasis. J Med Chem. 2025 Dec 11;68 (23) :24869-24889.