PMV6-PEG4-BI2536
PMV6-PEG4-BI2536 is a p53-Y220C-PLK1 dual-functional compound, composed of a high-affinity p53-Y220C mutant binder (Kd ≈ 2.5 nM) and a potent PLK1 kinase inhibitor (IC50 = 0.83 nM) . PMV6-PEG4-BI2536 triggers TP53Y220C cell G2/M arrest and apoptosis through PLK1 mislocalization and kinase inhibition, independent of p53 transcriptional reactivation. PMV6-PEG4-BI2536 can be used for the study of TP53 mutant cancers[1].
Product Specifications
UNSPSC
12352005
Target
MDM-2/p53; Polo-like Kinase (PLK)
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
Molecular Formula
C59H75F3N10O11S
Molecular Weight
1189.35
References & Citations
[1]Sadagopan A, et al. Mutant p53 protein accumulation is selectively targetable by proximity-inducing drugs. Nat Chem Biol. 2025 Nov 3.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PLK1
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