OPN-9643
OPN-9643 is a covalent inhibitor targeting the central palmitate binding pocket of TEADs with an IC50 of 15 nM, preventing autopalmitoylation and reducing TEAD-driven luciferase activity and canonical TEAD targets, CTGF and CYR61. OPN-9643 can be used for the research of cancer, such as melanoma[1].
Product Specifications
CAS Number
[2866423-06-3]
UNSPSC
12352005
Target
YAP
Related Pathways
Stem Cell/Wnt
Field of Research
Cancer
Smiles
C=CC(N1CC2=C(C=CC(OC3=CC=C(C(F)(F)F)C=C3)=C2)CC1)=O
Molecular Formula
C19H16F3NO2
Molecular Weight
347.33
References & Citations
[1]Ott CA, et al. Targeting TAZ-TEAD in minimal residual disease enhances the duration of targeted therapy in melanoma models. Nat Commun. 2025;16 (1) :9655. Published 2025 Nov 5.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TEAD
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS6186008-01 0.1 mL
DHX8 (DEAH (Asp-Glu-Ala-His) Box Polypeptide 8, DDX8, HRH1, PRP22, PRPF22) (PE)
Ask
View Details