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OPN-9643

OPN-9643 is a covalent inhibitor targeting the central palmitate binding pocket of TEADs with an IC50 of 15 nM, preventing autopalmitoylation and reducing TEAD-driven luciferase activity and canonical TEAD targets, CTGF and CYR61. OPN-9643 can be used for the research of cancer, such as melanoma[1].

Product Specifications

CAS Number

2866423-06-3

UNSPSC

12352005

Target

YAP

Related Pathways

Stem Cell/Wnt

Field of Research

Cancer

Smiles

C=CC(N1CC2=C(C=CC(OC3=CC=C(C(F)(F)F)C=C3)=C2)CC1)=O

Molecular Formula

C19H16F3NO2

Molecular Weight

347.33

References & Citations

[1]Ott CA, et al. Targeting TAZ-TEAD in minimal residual disease enhances the duration of targeted therapy in melanoma models. Nat Commun. 2025;16 (1) :9655. Published 2025 Nov 5.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

TEAD

Frequently Asked Questions

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