5-Bromo-UTP (trisodium)

5-Bromo-UTP (5-BrUTP) trisodium is a derivative of uridine triphosphate (UTP) . 5-Bromo-UTP trisodium can be utilized by cells as a precursor for RNA synthesis. During transcription, it integrates into the newly synthesized RNA chain and replaces some UTP. 5-Bromo-UTP trisodium can be used to label newly synthesized RNA, thereby enabling high-resolution visualization of transcriptional sites and RNA transport[1][2].

Product Specifications

Product Name Alternative

5-BrUTP (trisodium)

UNSPSC

12352211

Target

DNA/RNA Synthesis; Nucleoside Antimetabolite/Analog

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Others

Smiles

O[C@H]1[C@@H](O)[C@H](N2C=C(Br)C(NC2=O)=O)O[C@@H]1COP(OP(OP(O)(O[Na])=O)(O[Na])=O)(O[Na])=O

Molecular Formula

C9H11BrN2Na3O15P3

Molecular Weight

628.98

References & Citations

[1]Thiry M, et al. Dynamics and three-dimensional localization of ribosomal RNA within the nucleolus. RNA. 2000 Dec;6 (12) :1750-61.|[2]Cmarko D, et al. Ultrastructural analysis of nucleolar transcription in cells microinjected with 5-bromo-UTP. Histochem Cell Biol. 2000 Mar;113 (3) :181-7.