ISR activator 3

ISR activator 3 (Compound cc81) is the active metabolite of A8. ISR activator 3 activates the integrated stress response (ISR) by binding to RIG-I (KD ≈ 0.55 μM), without inducing lipid droplet clearance. ISR activator 3 enhances the interferon response under viral mimicry signals. ISR activator 3 can be used for research on neurodegenerative diseases and immune stress[1].

Product Specifications

CAS Number

[332950-12-6]

UNSPSC

12352005

Target

Eukaryotic Initiation Factor (eIF)

Related Pathways

Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Inflammation/Immunology; Neurological Disease

Smiles

CC1=C2C(SC(C(NC3=C(C(OCC)=O)C(C4=CC=CC=C4)=CS3)=O)=C2N)=NC(C)=C1

Molecular Formula

C23H21N3O3S2

Molecular Weight

451.56

References & Citations

[1]Cuoco CA, et al. Pharmacological targeting of RIG-I can selectively activate the integrated stress response. Sci Adv. 2025 Oct 31;11 (44) :eadt3014.