ISR activator 3
ISR activator 3 (Compound cc81) is the active metabolite of A8. ISR activator 3 activates the integrated stress response (ISR) by binding to RIG-I (KD ≈ 0.55 μM), without inducing lipid droplet clearance. ISR activator 3 enhances the interferon response under viral mimicry signals. ISR activator 3 can be used for research on neurodegenerative diseases and immune stress[1].
Product Specifications
CAS Number
332950-12-6
UNSPSC
12352005
Target
Eukaryotic Initiation Factor (eIF)
Related Pathways
Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Inflammation/Immunology; Neurological Disease
Smiles
CC1=C2C(SC(C(NC3=C(C(OCC)=O)C(C4=CC=CC=C4)=CS3)=O)=C2N)=NC(C)=C1
Molecular Formula
C23H21N3O3S2
Molecular Weight
451.56
References & Citations
[1]Cuoco CA, et al. Pharmacological targeting of RIG-I can selectively activate the integrated stress response. Sci Adv. 2025 Oct 31;11 (44) :eadt3014.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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