CKBA
CKBA, a derivative of AKBA is an inhibitor of acetyl-CoA carboxylase 1 (ACC1), with an IC50 of 5.02 μM. CKBA inhibits the differentiation of Th17 cells and has IC50 values of 3.28 μM for mouse cells and 3.61 μM for human cells. CKBA ointment significantly alleviates psoriasis-like inflammation in mice. CKBA can be used for the study of psoriasis[1].
Product Specifications
CAS Number
1786406-66-3
UNSPSC
12352100
Target
Acetyl-CoA Carboxylase; Drug Derivative
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Inflammation/Immunology
Smiles
O=C(O[C@H]1[C@@](C(O)=O)(C)[C@@](CC[C@]([C@@](CC[C@]2(C)[C@@]3([H])[C@@H](C)[C@H](C)CC2)(C)C3=C4)(C)[C@]5([H])C4=O)([H])[C@]5(C)CC1)C6CCCCC6
Molecular Formula
C37H56O5
Molecular Weight
580.84
References & Citations
[1]Lou F, et al. Identification and pre-clinical investigation of 3-O-cyclohexanecarbonyl-11-keto-β-boswellic acid as a drug for external use to treat psoriasis. Br J Pharmacol. 2024 Apr;181 (8) :1290-1307.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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