SOD1-aggregation-IN-1

SOD1-aggregation-IN-1 (compound 20) is a potent SOD aggregation inhibitor. SOD1-aggregation-IN-1 inhibits MG132 (HY-13259) -induced mutant SOD1 intracellular aggregation in PC12-SOD1G85R YFP cells with an EC50 of 2.63 μM. SOD1-aggregation-IN-1 can be used for amyotrophic lateral sclerosis (ALS) research[1].

Product Specifications

UNSPSC

12352101

Target

SOD

Related Pathways

Immunology/Inflammation

Field of Research

Neurological Disease

Smiles

O=C1CC(CC(C(C)(OC2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)C)C1)=O

Molecular Formula

C17H16F6O3

Molecular Weight

382.30

References & Citations

[1]Elmansy MF, et al. Modifications of NU-9, a potent protein aggregation inhibitor. Properties and activity in a cellular model of amyotrophic lateral sclerosis. Bioorg Chem. 2025 Dec;167:109190.