EGFR/InhA-IN-1

EGFR/InhA-IN-1 (Compound 15) is an inhibitor of the anti-cancer target EGFR tyrosine kinase (1M17) (Ki = 0.05 μM) and the anti-tuberculosis target InhA enzyme (1OUZ) (Ki = 0.02 μM) . EGFR/InhA-IN-1 exhibits anti-proliferative activity against A549 cells, with an IC50 of 10.38 μM. EGFR/InhA-IN-1 has inhibitory activity against Mycobacterium tuberculosis H37Rv, with a MIC of 6.25 μM. EGFR/InhA-IN-1 can be used for research on non-small cell lung cancer and Mycobacterium tuberculosis infection[1].

Product Specifications

UNSPSC

12352005

Target

Bacterial; EGFR

Related Pathways

Anti-infection; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Field of Research

Cancer; Infection

Smiles

O=C1N(C2=CC=CC=C2)C3=C(C=CC=C3)C4=C1C(C)=NN=C4C5=CC6=CC=CC=C6N=C5Cl

Molecular Formula

C27H17ClN4O

Molecular Weight

448.90

References & Citations

[1]Ghaith EA, et al. Rational design, synthesis of some quinolinone-Schiff bases/ pyridazino[4,5-c]quinolinones with potent anti-lung cancer and antituberculosis performance. Sci Rep. 2025 Nov 4;15 (1) :38497.