EGFR/InhA-IN-1
EGFR/InhA-IN-1 (Compound 15) is an inhibitor of the anti-cancer target EGFR tyrosine kinase (1M17) (Ki = 0.05 μM) and the anti-tuberculosis target InhA enzyme (1OUZ) (Ki = 0.02 μM) . EGFR/InhA-IN-1 exhibits anti-proliferative activity against A549 cells, with an IC50 of 10.38 μM. EGFR/InhA-IN-1 has inhibitory activity against Mycobacterium tuberculosis H37Rv, with a MIC of 6.25 μM. EGFR/InhA-IN-1 can be used for research on non-small cell lung cancer and Mycobacterium tuberculosis infection[1].
Product Specifications
UNSPSC
12352005
Target
Bacterial; EGFR
Related Pathways
Anti-infection; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Field of Research
Cancer; Infection
Smiles
O=C1N(C2=CC=CC=C2)C3=C(C=CC=C3)C4=C1C(C)=NN=C4C5=CC6=CC=CC=C6N=C5Cl
Molecular Formula
C27H17ClN4O
Molecular Weight
448.90
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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