DIM-3,5-Cl2
DIM-3,5-Cl2 is an inverse NR4A1/NR4A2 agonist. DIM-3,5-Cl2 can downregulate the pro-oncogenic responses/gene products regulated by NR4A1/NR4A2. DIM-3,5-Cl2 can induce ROS, malondialdehyde, and lipoperoxide formation, and this was accompanied by decreased expression of GPX4 and SLC7A11 and induction of CD71. DIM-3,5-Cl2 can induce ferroptosis. DIM-3,5-Cl2 can be used for the study of triple-negative breast cancer[1].
Product Specifications
CAS Number
2595179-74-9
UNSPSC
12352005
Target
Ferroptosis; Glutathione Peroxidase; Nuclear Hormone Receptor 4A/NR4A; Reactive Oxygen Species (ROS) ; Transferrin Receptor
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Vitamin D Related/Nuclear Receptor
Field of Research
Cancer
Smiles
ClC1=CC(Cl)=CC(C(C2=CNC3=C2C=CC=C3)C4=CNC5=C4C=CC=C5)=C1
Molecular Formula
C23H16Cl2N2
Molecular Weight
391.29
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Nur77/NR4A1; Nurr1/NR4A2
Frequently Asked Questions
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