Sino-C

Sino-C is a Sinomenine (HY-15122) derivative with anticancer activity. Sino-C broadly disrupts cholesterol homeostasis by upregulating key genes such as SREBF2 and HMGCS1, leading to intracellular cholesterol accumulation and lipid droplet formation. Sino-C-induced metabolic dysregulation further triggers lipid peroxidation and endoplasmic reticulum (ER) stress, initiating a unique form of hybrid cell death including apoptotic (cleaved PARP) and necrotic-like features. Sino-C thus serves as a useful compound for research in colorectal cancer, lung cancer and breast cancer[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; PARP

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics

Field of Research

Cancer

Smiles

O=C1C[C@@]2(CCN3C)C4=C(O)C(O)=CC=C4[C@@H](SCC5=CC=C(Cl)C=C5Cl)[C@@]3([H])C2C=C1OC

Molecular Formula

C25H25Cl2NO4S

Molecular Weight

506.44

References & Citations

[1]Zhang YM, et al. Sino-C, a novel sinomenine derivative, induces cell death bya novel sinomenine derivative, induces cell death by disrupting cholesterol homeostasis in colorectal cancer cells. Acta Pharmacol Sin. 2025 Nov 3. doi: 10.1038/s41401-025-01683-8. Epub ahead of print. PMID: 41184618.