ISR activator 2
ISR activator 2 is a selective ISR activator. ISR activator 2 can preferentially activate the ISR through the binding of the cytosolic pattern recognition receptor RIG-I, which subsequently activates the heme-regulated inhibitor (HRI) ISR kinase independent of an interferon response. ISR activator 2 can be used for the study of pancreatic cancer[1].
Product Specifications
CAS Number
332874-88-1
UNSPSC
12352005
Target
Eukaryotic Initiation Factor (eIF)
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer; Neurological Disease
Smiles
CC1=CC(C)=NC(SCC(NC2=C(C(OCC)=O)C(C3=CC=CC=C3)=CS2)=O)=C1C#N
Molecular Formula
C23H21N3O3S2
Molecular Weight
451.56
References & Citations
[1]Cuoco CA, et al. Pharmacological targeting of RIG-I can selectively activate the integrated stress response. Sci Adv. 2025 Oct 31;11 (44) :eadt3014.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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