Carba1
Carba1 is a bifunctional Carbazole derivative that activates nicotinamide phosphoribosyltransferase (NAMPT) and enhances NAD biosynthesis. Carba1 binds to colchicine site of tubulin, enhancing the anti-tumor effect of various chemotherapy drugs, such as Paclitaxel (HY-B0015). Carba1 exerts neuroprotective effect and can regulate cell energy metabolism. Carba1 can be used for the researches of cancer and chemotherapy-induced peripheral neuropathy (CIPN).
Product Specifications
CAS Number
2635394-10-2
UNSPSC
12352005
Target
Drug Derivative; Microtubule/Tubulin; NAMPT
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; Metabolic Enzyme/Protease; Others
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Smiles
CC1=CC(N2C=CC=C2)=C(C)C3=C1NC4=C3C=C(Cl)C=C4
Molecular Formula
C18H15ClN2
Molecular Weight
294.78
References & Citations
[1]Bosc L, et al. Preventing neuropathy and improving anticancer chemotherapy with a carbazole-based compound. Sci Adv. 2025 Oct 31;11 (44) :eadw6328.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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