EGFR-IN-186
EGFR-IN-186 is a potent inhibitor of EGFR with an IC50 of 0.065 µM. EGFR-IN-186 also exhibits inhibitory activity against EGFRL858R (IC50 = 0.528 µM) and EGFRT790M (IC50 = 0.465 µM) . EGFR-IN-186 induces apoptosis by increasing Bax and caspase-3 levels and down-regulating Bcl-2 expression level. EGFR-IN-186 can be used for the research of non-small cell lung cancer (NSCLC) [1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family; Caspase; EGFR
Related Pathways
Apoptosis; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
O=C(NC=N1)C2=C1N(C=C2C3=CC=CC=C3)C4=CC=C(S(=O)(NC5=NC(C)=CC(C)=N5)=O)C=C4
Molecular Formula
C24H20N6O3S
Molecular Weight
472.52
References & Citations
[1]El-Gazzar MGM, et al. Novel pyrrole-sulfonamide derivatives as EGFR inhibitors and radiosensitizers in lung cancer. Bioorg Chem. 2025;166:109173.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EGFR/ErbB1/HER1
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