CDK1-IN-8

CDK1-IN-8 is a CDK1 inhibitor. CDK1-IN-8 inhibits cell migration, induces apoptosis, and arrests the cell cycle at the G2/M phase. CDK1-IN-8 leads to a significant downregulation of CDK1 protein levels in HepG2 cells. CDK1-IN-8 can be used for the study of human hepatocellular carcinoma[1].

Product Specifications

CAS Number

[3077717-99-5]

UNSPSC

12352128

Target

Apoptosis; CDK

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Field of Research

Cancer

Smiles

OC1=C2C(C(C(C=C(C(NCCNC(C3=CC(F)=C(Cl)C=C3)P(OCC)(OCC)=O)=O)C=C4O)=C4C2=O)=O)=CC=C1

Molecular Formula

C28H27ClFN2O8P

Molecular Weight

604.95

References & Citations

[1]Li J, et al. Design, synthesis, and evaluation of phosphorylated rhein derivatives with enhanced antiproliferative activity. Bioorg Chem. 2025 Nov;166:109172.