XSJ151

XSJ151 is a topoisomerase I inhibitor, stabilizing the DNA-Topo I covalent complex and inducing DNA double-strand breaks. XSJ151-induced DNA damage activates the p53-p21 signaling pathway, specifically regulating the expression of cyclins, leading to G2/M phase cell cycle arrest and disrupting the dynamic homeostasis of Bcl-2 family proteins, thereby triggering apoptosis in gastric cancer cells. XSJ151 can be used for the study of gastric cancer[1].

Product Specifications

CAS Number

[1685279-23-5]

UNSPSC

12352005

Target

Bcl-2 Family; DNA/RNA Synthesis; MDM-2/p53; Topoisomerase

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Field of Research

Cancer

Smiles

COC(C=C1)=CC=C1CC(NCC(O[C@]2(CC)C(OCC3=C2C=C4N(CC5=CC6=CC=CC=C6N=C54)C3=O)=O)=O)=NS(C7=CC=C([N+]([O-])=O)C=C7)(=O)=O

Molecular Formula

C37H31N5O10S

Molecular Weight

737.73

References & Citations

[1]Si Z, et al. Camptothecin 20 (S) -sulfonyl amidine derivative inhibits gastric cancer cell proliferation by targeting topoisomerase I to trigger the DNA damage-apoptosis cascade. Bioorg Chem. 2025 Nov;166:109171.