Umbelopsisin A

Umbelopsisin A is a GABAA and GABAB non-selective agonist. Umbelopsisin A activates the GABAergic pathway, including notch signaling and fatty acid metabolism. Umbelopsisin A shows dual neuroprotection against glutamate excitotoxicity in vitro (reducing ROS and cell death) and in vivo. Umbelopsisin A can be used for the study of glaucoma and broader neurodegenerative disease applications[1].

Product Specifications

UNSPSC

12352005

Target

GABA Receptor; Reactive Oxygen Species (ROS)

Related Pathways

Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Smiles

CC1=C(O)C(C)=C(C)C([C@@]2(C3=CNC4=CC=CC=C43)C(OC)=O)=C1OC2=O

Molecular Formula

C21H19NO5

Molecular Weight

365.38

References & Citations

[1]Mo J, et al. A novel fungal alkaloid protects retinal ganglion cells against glutamate-induced excitotoxicity in vitro and in vivo via activation of GABA pathway. Bioorg Chem. 2025;166:109170.