ASK1-IN-12
ASK1-IN-12 is an ASK1 inhibitor with an IC50 of 6.3 nM. ASK1-IN-12 inhibits TNF-α-induced activation of the ASK1-p38/JNK pathway. ASK1-IN-12 can reduce free fatty acid-induced cholesterol increase, lipid droplet accumulation and improves hepatocellular steatosis. ASK1-IN-12 can be used for the research of non-alcoholic steatohepatitis (NASH) [1].
Product Specifications
UNSPSC
12352005
Target
ASK1; JNK; p38 MAPK
Related Pathways
Apoptosis; MAPK/ERK Pathway
Field of Research
Metabolic Disease; Inflammation/Immunology
Smiles
O=C(NC1=CC=CC(C2=NN=CN2[C@H](C(F)(F)F)C)=N1)C3=NN4C=CC(C5=CN(C(C)C)N=C5)=CC4=C3
Molecular Formula
C24H22F3N9O
Molecular Weight
509.49
References & Citations
[1]Liu H, et al. Pyrazolopyridine derivatives as potent ASK1 inhibitors: design, synthesis, and biological evaluation. Bioorg Chem. 2025;167:109176.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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