BSJ-04-146

BSJ-04-146 is a highly efficient and selective PROTAC targeting focal adhesion kinase (FAK) (IC50 = 26 nM) . BSJ-04-146 achieves rapid and potent FAK degradation with high proteome-wide specificity in cancer cells and induces durable degradation in mice. BSJ-04-146 binds FAK and requires the ubiquitin-proteasome machinery to achieve FAK degradation. BSJ-04-146 can be used for the study of pancreatic cancer and triple-negative breast cancer[1].

Product Specifications

CAS Number

[2414478-45-6]

UNSPSC

12352005

Target

FAK; PROTACs

Related Pathways

PROTAC; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

O=C(NC)C1=CC=CC=C1NC2=CC(NC3=CC(C)=C(C4CCN(CCCCCCNC(COC5=CC=CC(C(N6C(CC7)C(NC7=O)=O)=O)=C5C6=O)=O)CC4)C=C3OC(C)C)=NC=C2C(F)(F)F

Molecular Formula

C50H57F3N8O8

Molecular Weight

955.03

References & Citations

[1]Koide E, et al. Development and Characterization of Selective FAK Inhibitors and PROTACs with In Vivo Activity. Chembiochem. 2023 Oct 4;24 (19) :e202300141.