CDD-1274
CDD-1274 is an ERα (Estrogen receptor α) variant inhibitor. CDD-1274 induces proteasomal degradation of ERα variants in breast cancer cell lines and causes Y537S ERα degradation. CDD-1274 potently blocks ligand-dependent and ligand-independent ER signaling in endocrine-resistant breast cancer cells. CDD-1274 can be used for the study of breast cancer[1].
Product Specifications
UNSPSC
12352005
Target
Estrogen Receptor/ERR
Related Pathways
Vitamin D Related/Nuclear Receptor
Field of Research
Cancer
Smiles
O=C(NC)CCOCCC(N1CC(C2NCC3=CC(C4=CC(O)=CC=C4OC(F)(F)F)=CC=C3F)CCC2C1)=O
Molecular Formula
C28H33F4N3O5
Molecular Weight
567.57
References & Citations
[1]Devakrishnan AK, et al. Discovery of a novel small molecule degrader of wild type and mutant estrogen receptors using DNA encoded libraries. NPJ Breast Cancer. 2025 Nov 12;11 (1) :125.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ERα
Curated Selection
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