COX-2/5-LOX-IN-5

COX-2/5-LOX-IN-5 is a dual COX-2 and 5-LOX inhibitor with IC50 values of 0.84 μM and 0.46 μM, respectively. COX-2/5-LOX-IN-5 binds to the active sites of both COX-2 and 5-LOX, and effectively inhibits prostaglandin and leukotriene-mediated inflammation. COX-2/5-LOX-IN-5 can be used for the research of inflammation[1].

Product Specifications

UNSPSC

12352005

Target

COX; Lipoxygenase

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease

Field of Research

Inflammation/Immunology

Smiles

O=S(NN([Zn](OC(C)=O)OC(C)=O)C1=CC=C([N+]([O-])=O)C=C1[N+]([O-])=O)(C2=CC=C(C)C=C2)=O

Molecular Formula

C17H17N4O10SZn

Molecular Weight

534.78

References & Citations

[1]Rahman M, et al. Design, synthesis, characterization, biological investigation and docking studies of newly synthesized sulphonyl hydrazide and their derivatives. Sci Rep. 2025;15 (1) :39527. Published 2025 Nov 11.